Alpha-1 antitrypsin, also known as an alpha-1 protease inhibitor (A1PI), is a glycoprotein produced in the liver that helps in the inactivation of enzymes such as elastase, which break down proteins during inflammation induced by some injury. The decline in alpha-1 antitrypsin levels in the blood results in a rare genetic condition known as alpha-1 antitrypsin deficiency (AATD), which leads to the development of respiratory and liver diseases, and severe skin infections. The disease is passed on from parents to an offspring through mutated genes. Augmentation therapy using drugs derived from human plasma helps in maintaining levels of alpha-1 antitrypsin in the blood, helping in remission of the condition.
The analysts forecast global alpha-1 antitrypsin drugs market to grow at a CAGR of 35.42% during the period 2016-2020.
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According to the Alpha-1 Antitrypsin Drugs market report, a key driver is the improved diagnosis of AATD. AATD is difficult to diagnose in the majority of cases. The Alpha-1 Foundation reports that around 3% of all people who have diagnosed with COPD may have undetected AATD. The condition is misdiagnosed in most of the cases as asthma, smoking-related COPD, bronchitis, bronchiectasis, or other pulmonary conditions. These underlying conditions may confuse the clinical picture and thus lead to the difficulty in diagnosis. However, awareness programs conducted by various organizations worldwide will help in recognizing and differentiating the condition from other diseases. For example, the Alpha-1 Foundation conducts support programs which include Alpha-1 Kids, Genetic Counselling Program, Caregivers Support Group, and education days at different locations throughout the US and an annual National Education Conference.
The global Alpha-1 Antitrypsin Drugs market analyst said increased awareness about therapy is helping market growth. Alpha-1 antitrypsin deficiency (AATD) is a common yet under-recognized condition. The individuals do not recognize the symptoms, need for diagnosis, and the potentially life-threatening consequences of alpha-1 antitrypsin, thus demonstrating the need for increased awareness. Many charitable trusts and organizations are engaged in spreading awareness.
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This report covers the present scenario and the growth prospects of the global alpha-1 antitrypsin drugs market for 2016-2020. To calculate the market size, the report considers the revenue generated from the sales of branded drugs and off-label drugs used for the symptomatic treatment of diseases occurring due to alpha-1 antitrypsin deficiency and other disorders.
The market is divided into the following segments based on geography:
The report, Global Alpha-1 Antitrypsin Drugs Market 2016-2020, has been prepared based on an in-depth market analysis with inputs from industry experts. This report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market.
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Key key players in the Global Alpha-1 Antitrypsin Drugs Market: Baxter International, CSL Behring, Grifols, and Kamada.
Other Prominent Vendors in the market are: Abeona Therapeutics, Alnylam Pharmaceuticals, Applied Genetic Technologies, Arrowhead Research, Baxalta, Biogen, Chiesi, Curaxys, Laboratoire français du Fractionnement et des Biotechnologies, ProBioGen, and ProMetic Life Sciences.
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