Cyclin Dependent Kinase 7 (39 kDa Protein Kinase or CDK Activating Kinase 1 or Cell Division Protein Kinase 7 or TFIIH Basal Transcription Factor Complex Kinase Subunit or Serine/Threonine Protein Kinase 1 or CDK7 or EC 18.104.22.168 or EC 22.214.171.124) - Cell division protein kinase 7 is an enzyme that in humans is encoded by the CDK7 gene.
CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. It phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. thus regulating cell cycle progression. Upon DNA damage it triggers p53/TP53 activation by phosphorylation but is inactivated in turn by p53/TP53. This feedback loop leads to an arrest of the cell cycle.
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Major Key Players:
Aurigene Discovery Technologies Ltd
Beta Pharma Inc
Cyclacel Pharmaceuticals Inc
Qurient Co Ltd
Syros Pharmaceuticals Inc
Cyclin Dependent Kinase 7 Industry Major Outlook
Pharmaceutical and Healthcare latest pipeline guide Cyclin Dependent Kinase 7 - Pipeline Review, H1 2018, provides comprehensive information on the therapeutics under development for Cyclin Dependent Kinase 7 , complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.
Cyclin Dependent Kinase 7 (39 kDa Protein Kinase or CDK Activating Kinase 1 or Cell Division Protein Kinase 7 or TFIIH Basal Transcription Factor Complex Kinase Subunit or Serine/Threonine Protein Kinase 1 or CDK7 or EC 126.96.36.199 or EC 188.8.131.52) pipeline Target constitutes close to 10 molecules. Out of which approximately 9 molecules are developed by companies and remaining by the universities/institutes. The molecules developed by companies in Phase II, Phase I, Preclinical and Discovery stages are 4, 1, 3 and 1 respectively.
Cyclin Dependent Kinase 7 pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage.
Cyclin Dependent Kinase 7 - Competitive Analysis
Key players are making innovative developments in Cyclin Dependent Kinase 7 industry. The same will help in improving the market performance. Heavy investments are made by major players in the R&D sector
The pipeline guide provides a snapshot of the global therapeutic landscape of Cyclin Dependent Kinase 7.
The pipeline guide reviews pipeline therapeutics for Cyclin Dependent Kinase 7 by companies and universities/research institutes based on information derived from company and industry-specific sources.
The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.
The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
The pipeline guide reviews key companies involved in Cyclin Dependent Kinase 7 therapeutics and enlists all their major and minor projects.
The pipeline guide evaluates Cyclin Dependent Kinase 7 therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.
The pipeline guide encapsulates all the dormant and discontinued pipeline projects.
The pipeline guide reviews latest news related to pipeline therapeutics for Cyclin Dependent Kinase 7.
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